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The need for improved tools within the proteomic field is an ongoing, rapidly evolving endeavour. Today, I detail a novel approach utilizing a chemical biology strategy denoted as activity-based probes (ABPs). The aim is to functionally profile enzyme classes in their activity state. In the following example, metallo-aminopeptidases was profiled based upon synthesizing the bestatin inhibitor scaffold. It is the first synthesis of bestatin analogues using solid-phase techniques.
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In The Halloween Tree, a 1972 novel by American horror, science-fiction and fantasy writer Ray Bradbury, eight children go trick-or-treating. Can you find them in the book's cover? In this ambiguous illusion, the costumed kids, their props and the tree in the background form the shape of a skull. Step back from the scene or squint your eyes if you have trouble seeing the skull. To identify the trick-or treaters, get close again, paying attention to the details in the image.
Aristolochiaceae are a flowering plants family, with about 500 species. Other common names are birthworts, pipevines or dutchman's pipes. The “pipe” names are an allusion to old-fashioned meerschaum pipes, similar to the flower shape of this plants and “birthwort” refers to the function of these flowers as birth canal for some insects , e.g. Pipevine Swallowtail, a swallowtail butterfly found in North America and Central America. There are herbaceous plants, which can become either shrub, woody vines or even lianas.
Nafamostat mesylate inhibits coagulation and fibrinolysis.
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