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Rolipram is commonly known as a drug used to treat depression. It is in the family of drugs referred to as monoamine oxidase inhibitors (MAOI). It promotes the release of norepinepherine, which in term produces a better mood and an alleviation of depression symptoms.
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Figure 1: Potential signaling pathways involved in anthracycline-induced cardiomyocyte injury.
Ansamycins is a family of secondary metabolites that show antimicrobial activity against many gram-positive and some gram-negative bacteria and includes various compounds, among which: streptovaricins and rifamycins. In addition, these compounds demonstrate antiviral activity towards bacteriophages and poxviruses.
Withaferin A (WA) is derived from the medical plant Withania somnifera (commonly known as ashwagandha or Indian winter cherry), which has been safely used for centuries in Indian Ayurvedic medicine for treatment of different ailments. Suppresion of angiogenisis, alteration of cytoskeletal architecture, and inhibition of proteasomal activity by WA has also been documented.
