Tweaking The Immune System Can Help Fight Cancer & Block Angiogenesis

Posted by Jannel Reyes on Aug 6, 2013 9:36:00 AM

Cancers that become resistant to an important class of drugs might be made vulnerable by tweaking the immune system, a team led by UCSD researcher Napolene Ferrara has found.

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Tags: antibiotics, cancer, cancer research, anticancer, IMMUNE SYSTEM, biochemicals, angiogenesis, white blood cells, cancer drugs, tumors, tumor growth

G-418 FAQS (Frequently Asked Questions)

Posted by Jannel Reyes on May 20, 2013 9:42:00 AM

For the last 15 years, A.G. Scientific has been a leading manufacturer, and supplier of g-418, Geneticin®.  Our success with a combination of fermentation & synthesis that has allowed us to build a catalog of over 160 antibiotics and a customer base of researchers, catalog biochemical distributors and cell media manufacturers worldwide. Click here for our Comprehensive Antibiotic E-Guide. We offer the full range of services: custom bottling, sterile formulations, custom packaging, as well as, a full suite of private labeling capabilities.   

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Tags: G-418, g418, antibiotics, antibiotic, biochemicals


Posted by Jannel Reyes on May 7, 2013 7:21:00 AM


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Tags: inhibitor, biotech, drug, biology, immunosuppressant, rapamycin, sirolimus, biochemicals

Treating Cancer Using Epirubicidin

Posted by Jannel Reyes on Aug 9, 2012 10:50:00 AM

MECHANISM OF ACTIONThe mechanism of action of epirubicin appears to be related to its ability to bind to nucleic acids. It forms a complex with DNA by intercalation between base pairs, resulting in inhibition of DNA and RNA synthesis. Intercalation also triggers DNA cleavage by topoisomerase II, resulting in cytocidal activity. Binding to cell membranes and plasma proteins may also be involved. Epirubicin also generates cytotoxic free radicals. Epirubicin is the 4’-epimer of DOXOrubicin; i.e., there is a different spatial orientation of the hydroxyl group at the 4’ carbon of the sugar moiety. This difference may account for faster elimination and reduced toxicity.

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Tags: research, antibiotics, cancer, agscientific, study, epirubicidin, antineoplastic, chemotherapy, biochemicals, anthracycline

Benzoquinonoid Ansamycins Antibiotics

Posted by John Kim on May 17, 2012 1:00:00 PM

Ansamycins is a family of secondary metabolites that show antimicrobial activity against many gram-positive and some gram-negative bacteria and includes various compounds, among which: streptovaricins and rifamycins. In addition, these compounds demonstrate antiviral activity towards bacteriophages and poxviruses.

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Tags: biotechnology, antibiotics, antibiotic, 17-AAG, tumor, Hsp90, anti-inflammatory, anti-cancer and anti-tumor, biology, chemical, 17AAG, heat shock proteins, GELDANAMYCIN, 17-dmag, oncosis, hsp90 function, geldanamycin hsp90, Tumoricidal, ansamycins, biochemicals, anti-angiogenesis, angiogenesis, antiangiogenesis, CA;LIFORNIA BIOMEDICAL COMPANY, heat shock protein 90, antibiotic guide

Paclitaxel - A Mitotic Inhibitor Used in Cancer Chemotherapy

Posted by Jannel Reyes on May 3, 2012 2:03:00 PM

  • CAS #: 33069-62-4
  • Chemical Name: Taxol, Baccatin III N-benzyl-β-phenylisoserine ester
  • Chemical Formula: C47H51NO14
  • Appearance: White Crystalline Powder
  • Merck Index: 12.7117.1996
  • Molecular Weight: 853.9
  • Solubility: Soluble in DMSO, Ethanol, Methanol; Clear colorless solution at 10 mg/ml DMSO and 10 mg/ml methanol
  • Storage Temp: -20°C
  • Melting Point: 215-217°C
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Tags: inhibitor, cancer, anticancer, ACADEMIC RESEARCH, anti-cancer, anti-tumor, mitotic inhibitor, pacific, yew, pacific ye, paclitaxel, taxus bervifolia, yew family, taxaceae, taxol, natural product, natural, taxus, vinblastine, cytokine, release, modulation, antitumor activity, carcinomas, therapy, aggressive, elderly, melanoma, biochemical, biochemicals, bio, microtubule

Piperlonguminine: Potential Treatment For Alzheimer's Disease

Posted by Julia Hilsinger on May 1, 2012 10:49:00 AM

Piperlonguminine is a potential novel therapeutic agent for Alzheimer’s disease.  Extracellular deposits of Aβ in senile plaques of the cerebral cortex are known to be hallmarks of Alzheimer’s disease.  Recent studies show that a mix of piperlonguminine and dihydropiperlonguminine significantly inhibit the expression of Amyloid Precursor Protein (APP).  The decreased production of the peptide Amyloid β (Aβ) in SK-N-SH cells is a beneficial effect to Alzheimer’s Disease.


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Tags: biocom, alzheimers disease, biology, amino, BIOMARKER, biochemical, biochemicals, BIOLOGICAL DETERGENT SELECTION, biodetergents, bio detergent chaps, biological detergent, BIODETERGENT PURIFICATION MEMBRANE BOUND PROTEIN, amyloid precursor protein, cytoxic effect, cadida tropicalis, bacillus subtilis, piperlonguminine, alzheimer's treatment, amino acid, biological, antiviral, calcium, bioinformatically, biochemically

Chemotin and HIF-1

Posted by David DeMoranville on Mar 21, 2012 7:38:00 AM

Hypoxia-inducible factor-1 (HIF-1) is a transcriptional complex that is activated in response to hypoxia and growth factors. HIF-1 plays a central role in tumor progression, invasion, and metastasis. Overexpression of the HIF-1α subunit has been observed in many human cancers and is associated with a poor prognostic outcome with conventional treatments. Targeting HIF-1 using novel small molecule inhibitors is, therefore, an attractive strategy for therapeutic development.

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Tags: academic, stem cell, biotechnology, anticancer, antibiotic, ACADEMIC RESEARCH, anti-cancer, anti-tumor, IMMUNOSUPPRESANT, adult stem cell, cancer stem cell, biochemical, biochemicals, BIOMEDICAL RESEARCH, immunosuppressive, antifungal, anti-angiogenesis, BIOMARKERS IN CANCER, laboratory research, angiogenesis, stem cells, bioproduction, chetomin

Cycloheximide-induced T-cell Death Is Mediated by a Fas-associated Death Domain-dependent Mechanism

Posted by Jannel Reyes on Mar 20, 2012 11:24:00 AM

Cycloheximide (CHX) can contribute to apoptotic processes, either in conjunction with another agent (e.g. tumor necrosis factor-α) or on its own. The apoptotic process is now known to involve the well orchestrated interactions of cell death receptors, death receptor adaptors, caspases, and Bcl-2 family members. Although a number of stimuli have been reported to result in the up-regulation of the Fas receptor and its ligand (e.g. UV, c-Myc, and certain chemotherapeutic drugs), there are many other stimuli for which the mechanism responsible for their action is still unknown. An example of the latter is the ability of cycloheximide (CHX) to either promote or inhibit apoptosis in divergent cell types and in response to varying death stimuli. A large body of evidence has shown that CHX can potentiate, and in some cases (e.g. TNFα stimulation and staurosporine) be necessary for, the apoptotic effects of certain death stimuli. The studies of Martin et al. and Tuschida et al. further indicated that CHX, independently of other stimuli, is also capable of promoting apoptosis in a number of transformed cell lines and normal cells. Jacobsonet al. has shown that staurosporine- and staurosporine/cycloheximide-induced death is mediated by a caspase-3-like activity that is blocked by Z-VAD-FMK, a synthetic tripeptide inhibitor that demonstrates broad caspase specificity. More recently, Woo et al. demonstrated that bone marrow neutrophils from caspase-3−/− mice no longer undergo CHX-induced apoptosis, indicating that caspase-3 expression is most likely required for this type of cell death.

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Tags: biotech, biotechnology, apoptosis, CELL BIOLOGY, actidione, biology, molecular biology, biochemical, biochemicals, BIOMEDICAL RESEARCH, bioproduction