Image: Transcription Network — guarding the genome by sensing DNA damage. Courtesy of: [Mats Ljungman & David P. Lane Nature Reviews Cancer 4, 727-737 (September 2004) doi:10.1038/nrc1435]Read More
One of our most popular antibiotics, anisomycin, is a protein and DNA synthesis inhibitor that specializes in inhibiting the 80S ribosome network (eukaryotes). Anisomycin’s properties of inhibition become activated when concentrations are enough to effect greater than 95% of the 80S ribosome protein synthesis. Additionally, Anisomycin works by activating the stress response via the MAP kinase signal transduction pathway.Read More
The broadly held idea that memory formation in the brain is the cause of protein synthesis was challenged in light of data released by US researchers. By injecting a protein synthesis inhibitor, Anisomycin, into the brain, researchers then found they could boost certain levels of neurotransmitters. Specifically, by elevating the levels of noradrenalin, dopamine, and serotonin within the amygdala, researchers produced the desired effect of amnesia in rats .Read More
Our current knowledge...Read More
Life originated on Earth first because of light, as we discussed last week (How Did Protein Synthesis Originate?). Life originated in the presence of Earth’s day and night cycles that most present-day organisms (from bacteria to plants to animals) come equipped with a rich internal clock system that dictates many different behaviors at different times of the day.Read More
The molecular maps that exist today, the ones that continually improve and become more accurate, already seems inextricably complex (See Also: New Tissue Atlas Shows Protein Distribution Within the Human Body). We have the concepts of DNA transcription down, and the events of translation are well understood. What can be difficult to imagine is how protein synthesis came to be in the first place when so many interlocking pieces are involved and required. Obviously these systems could not have worked without the apparatus already in place, so how did it all come about?Read More
A.G. Scientific, Inc. is excited to be able to offer our clients a large selection of fluorescent dyes, reagents and imaging kits useful in fluorescent microscopy, in situ hybridization, flow cytometry, multi-well assays, content screening, reporter assays, and many more.Read More
The major biochemicals which People profile most commonly are proteins obtained from beef, the pancreas, plants, and through fermentation.
Let us briefly survey three particularly useful biochemical tools that could serve as the building blocks of your research.
The transformation of human health in society by vaccines is probably one of the greatest achievements in science. At the moment, the most obvious and visible signs that the facts are not in clear alignment with the truths presented by science, is the great, late vaccine debate. For better or for worse, much of the public argument over whether vaccines are a good or bad thing is really an argument about the value of the technology, and is not necessarily about the enterprise of science. Walking on the moon was a triumph of world-class engineering, which included nearly two centuries of classical physics distilled out by scientists like my Uncle Frank who helped design the original polymer used as the insulating material for the heat shield – who hadn’t the faintest idea of what it would be like to walk on the moon. Penicillin is another technology made possible by sixty years of scientific research in bacteriology, by the work of scientists who studied, in painstaking detail, the names and identities of bacteria, their habits, their diet and metabolism, just so they could have enough knowledge required to figure out that it takes Streptococcus and Staphylococcus in hand with the Penicillium fungus before you can even begin to consider such things as antibiotics.
Likewise is the case with vaccines. They represent one aspect of science that may be regarded, one long awaiting day, as the most important advancement for human health. This is the most heart-gut-wrenching news of all (in the Western world, anyway) is that a vast percentage of the population is forgoing basic inoculations out of fear it causes autism in young children. Understandably, many parents are weary from the science and a bit skeptical of the idea that a vaccine’s advertised value actually comes with the protection it provides, in this case, for their child.Read More